The meaning of PRESCRIBE is to lay down a rule : dictate. How to use prescribe in a sentence. The product will have to meet internationally prescribed (= demanded) standards. Definition of prescribe verb from the Oxford Advanced Learner's Dictionary. (of a doctor) to tell somebody to take a particular medicine or have a particular treatment; to write a prescription for a particular medicine, etc. prescribe something Valium is usually prescribed to treat anxiety. 2 meanings: 1. recommended by a doctor 2. laid down or recommended formally. Click for more definitions. Prescribe a course of action To recommend a specific procedure or process. The consultant prescribed a course of action to improve the company's efficiency. PRESCRIBE definition: to lay down, in writing or otherwise, as a rule or a course of action to be followed; appoint, ordain, or enjoin. See examples of prescribe used in a sentence. 1. To set down as a rule, law, or direction: prescribed the terms of the surrender. 2. To order the use of (a medicine or other treatment).