Promethazine HCl and Codeine Phosphate Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper. Promethazine with Codeine Oral Solution is a federal controlled substance (C-V) because it contains codeine that can be abused or lead to dependence. Keep Promethazine with Codeine Oral Solution in a safe place to prevent misuse and abuse. What is Promethazine with Codeine? Promethazine with Codeine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Ingredients for creating lean, including codeine - promethazine cough syrup, Jolly Rancher candies, and Sprite. Note the label on the bottled syrup, printed with instructions on how to prepare the lean. Some of the syrup has been decanted into a plastic container. A spoonful of promethazine/ codeine syrup showing the characteristic purple color Typically, the base for lean is a strong. Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Medscape - Cough dosing for promethazine/codeine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. What is Promethazine VC with Codeine? Promethazine VC with Codeine is a combination medicine used to treat runny or stuffy nose, sneezing, cough, and sinus congestion caused by allergies or the common cold. Promethazine VC with Codeine contains a narcotic cough medicine and may be habit-forming. Promethazine HCl and Codeine Phosphate Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Find patient medical information for Promethazine/Codeine on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Promethazine with codeine is a combination medication containing a phenothiazine and an opioid. It's used to treat cough and nasal symptoms caused by respiratory infections or allergies in adults. Promethazine with codeine comes as an oral solution that's taken by mouth every 4 to 6 hours.