What is Promethazine with Codeine? Promethazine with Codeine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Learn about Promethazine VC with Codeine usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Promethazine HCl and Codeine Phosphate Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper. Medscape - Cough dosing for promethazine/codeine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Find patient medical information for Promethazine/Codeine on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Promethazine with codeine is a combination medication containing a phenothiazine and an opioid. It's used to treat cough and nasal symptoms caused by respiratory infections or allergies in adults. Promethazine with codeine comes as an oral solution that's taken by mouth every 4 to 6 hours. Promethazine HCl and Codeine Phosphate Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Easy-to-read patient leaflet for Promethazine and Codeine. Includes indications, proper use, special instructions, precautions, and possible side effects. Does promethazine contain codeine? The antihistamine promethazine does not inherently contain codeine, but the two medications are frequently combined into a single prescription product.