For as-needed (PRN) anxiety management, propranolol 10-40 mg taken 30-60 minutes before an anxiety-provoking situation is the recommended approach, with most patients responding to 20-40 mg as a single dose. 1 Immediate-release propranolol will clear out of your body in about 1 to 2 days after your last dose, but the therapeutic effects may only last about 8 to 12 hours. The typical propranolol dosage depends on what you’re taking it for. Most adults take between 80 mg and 240 mg of propranolol daily. The ER capsules are typically taken once a day, but the tablets and solution are usually divided into smaller doses taken throughout the day. The standard propranolol dosage for hypertension is 40 mg tablet twice per day. Use our propranolol dosage chart to find the recommended and maximum dosage. Medscape - Hypertension-specific dosing for Inderal, Inderal LA (propranolol), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules. Detailed Propranolol dosage information for adults and children. Includes dosages for Hypertension, Migraine Prophylaxis, Myocardial Infarction and more; plus renal, liver and dialysis adjustments. NHS medicines information on dosage for propranolol, how to take it and what to do if you miss a dose or take too much. The elimination half-life of propranolol ranges from 2.8 to 8 hours in different studies, with a typical half-life of around 4 hours. [2][3] The duration of action of a single oral dose is longer than the half-life and may be up to 12 hours if the single dose is high enough (e.g., 80 mg). NHS medicines information on propranolol – what it's used for, side effects, dosage and who can take it. Your dose may need to be changed several times in order to find out what works best for you. This medicine should come with a Medication Guide and patient directions. Read and follow these instructions carefully. Ask your doctor if you have any questions.