Biochem/physiol Actions (S)- (−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)- (−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine. Propranolol Hydrochloride is the hydrochloride form of propranolol, a synthetic beta-adrenergic receptor blocker with antianginal, antiarrhythmic, and antihypertensive properties. Propranolol is a beta-blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. Propranolol tablets are a beta-blocker that treats high blood pressure, tremors and atrial fibrillation. It can also prevent migraine headaches. Propranolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. How should this medicine be used? Propranolol comes as a tablet, solution (liquid), and as an extended-release (long-acting) capsule to take by mouth. Propranolol is a beta-blocker that is used to treat high blood pressure, angina, anxiety, heart rhythm disorders, migraine prevention, and other heart or circulatory conditions. Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Inderal is available as 10 mg, 20 mg, 40 mg, 60. Propranolol is not recommended for the treatment of high blood pressure by the Eighth Joint National Committee (JNC 8) because a higher rate of the primary composite outcome of cardiovascular death, myocardial infarction, or stroke compared to an angiotensin receptor blocker was noted in one study. [24][23] Find patient medical information for Propranolol (Inderal LA, Innopran XL, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.