What is PROVERA? PROVERA is a medicine that contains medroxyprogesterone acetate, a progestin hormone. Provera is a progestin hormone used to treat menstrual periods that have stopped, abnormal uterine bleeding and to reduce the chances of getting uterine cancer. Medroxyprogesterone (Provera) treats conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Includes medroxyprogesterone side effects, interactions and indications. Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens. This medicine is a progestin hormone. Find patient medical information for Medroxyprogesterone (Provera, Depo-Provera, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. PROVERA is a medicine that contains medroxyprogesterone acetate, a progestin hormone. What is PROVERA used for? PROVERA is used to: Treat menstrual periods that have stopped or to treat abnormal uterine bleeding. PROVERA tablets are indicated for the treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer. Provera is a form of progesterone (a hormone) that is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Provera is also used to decrease the risk of endometrial hyperplasia (a condition that may lead to uterine cancer) while taking estrogens. Provera mimics progesterone, which helps regulate your menstrual cycle and thin your uterine lining. Taking Provera can significantly reduce or stop menstrual bleeding. Medroxyprogesterone tablets are used to treat heavy, painful or irregular periods. They're also sometimes used in the treatment of: Medroxyprogesterone tablets are a type of medicine called progestogens. They work like the hormone progesterone, which your body makes.