Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil improves quality of life and satisfaction for treated men and is well tolerated with a favorable safety profile. New data suggest that sildenafil has beneficial effects in several chronic conditions. It has been approved for the treatment of idiopathic pulmonary hypertension. Sildenafil, which is a specific phosphodiesterase type V inhibitor, enhances erection on sexual arousal by increasing the quantity of cyclic guanosine monophosphate in the corpora cavernosa. This has revolutionized the treatment of erectile dysfunction. Sildenafil and nitrates should not be taken together because they can both lower blood pressure. The potential hypotensive effects of each medicine when combined could result in significant life threatening side effects. Here, we’ll discuss more about sildenafil’s common interactions and how you and your healthcare team can manage them together. Certain sildenafil interactions are serious and should be avoided altogether. Other interactions are less serious, but your prescriber may still need to monitor you closely. Understanding the right dosage is key to maximizing benefits while minimizing risks. This guide breaks down typical doses, timing, and adjustments to help you use sildenafil safely and effectively. Sildenafil is used to treat erectile dysfunction in adult men or pulmonary arterial hypertension in adults and children, depending on the brand or formulation. Includes sildenafil side effects, interactions, and indications. Sildenafil is used to treat erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Many randomized controlled trials have evaluated sildenafil for the treatment of men with ED. However, we are unaware of any systematic review and quantitative meta-analysis that has formally evaluated the efficacy and safety of sildenafil therapy. Learn about the side effects of sildenafil, from common to rare, for consumers and healthcare professionals.