Ezetimibe is a prescription drug used to treat hypercholesterolemia. Learn about side effects, dosages, drug interaction, and more. Ezetimibe is a medicine used to lower cholesterol in people who have high blood cholesterol. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your intestines. Overview: Ezetimibe is a cholesterol-lowering medicine used to lower bad cholesterol (LDL-C) levels, including in people with certain inherited cholesterol conditions. It works by blocking the. Ezetimibe is a cholesterol absorption inhibitor. This medicine will reduce the absorption of cholesterol from foods and the production of cholesterol in your body. Ezetimibe (brand name: Zetia) is a prescription medicine that can be used in combination with a statin or fenofibrate to treat high cholesterol. It is used to lower levels of cholesterol in the blood. Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells lead them to absorb more cholesterol from circulation thus lowering the levels of circulating cholesterol. Ezetimibe is used to treat high blood cholesterol. You may also be prescribed ezetimibe if you cannot take cholesterol-lowering medicines called statins, or if a statin medicine does not work for you. Ezetimibe is a prescription medicine that helps lower the amount of low-density lipoprotein or LDL (“bad” cholesterol) in your blood. It does this by keeping your small intestine from absorbing cholesterol. View ezetimibe information, including dose, uses, side-effects, pregnancy, breast feeding and drug action. Find out how ezetimibe treats high blood cholesterol and how to take it. NHS medicines information on ezetimibe – what it's used for, side effects, dosage and who can take it.