Systemic focuses on the whole system and its parts. Systematic focuses on the method used to do something. For example, a problem that affects an entire organization can be systemic, while a careful step-by-step review of that problem can be systematic. Systematic and systemic both come from system. Systematic is the more common word; it most often describes something that is done according to a system or method. Systemic describes what relates to or affects an entire system, be that system physical, organizational, or societal. SYSTEMIC definition: of or relating to a system, especially when affecting the entirety of a thing. See examples of systemic used in a sentence. This disambiguation page lists articles associated with the title Systemic. If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article. In simplest terms, something described as systematic uses or follows a system, while something described as systemic is part of, or is embedded in, the system itself. Systemic inflammation affects your whole body and can quietly drive disease over time. Learn what causes it, how to recognize it, and ways to reduce it. 1. of or pertaining to a system. 2. pertaining to, affecting, or circulating through the entire body: systemic disease; systemic pesticide. SYSTEMIC definition: 1. A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant…. Learn more. Systemic chemicals or drugs are absorbed into the whole of an organism such as a plant or person, rather than being applied to one area. Systemic – born out of a deep desire to bring our vision to life, to create something authentic and to craft pieces that embody timelessness and individuality.