The following medications may decrease levels and effects of topiramate: carbamazepine (Tegretol®), phenytoin (Dilantin®), valproate (Depakote®) and phenobarbital Description Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine. In patients with or without a history of seizures or epilepsy, antiepileptic drugs, including TOPAMAX, should be gradually withdrawn to minimize the potential for seizures or increased seizure. Topiramate is a medication that treats epilepsy and it can also prevent migraine headaches. It works by calming overactive nerves in your body. Topamax (Topiramate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Topamax (topiramate) is an anticonvulsant medication used to treat epilepsy and migraine headaches. 1 It's also used off-label to treat a wide range of mood and eating disorders and to aid in substance abuse therapy. Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine headaches. Learn about side effects, interactions and indications. Find patient medical information for Topiramate (Topamax) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Topiramate, marketed as Topamax among other names, is an oral medication primarily prescribed for the treatment of epilepsy and the prophylaxis of migraines. [8] Learn the usual Topamax (topiramate) dosing schedules for migraine and seizures. Find critical info on forms, strengths, and pediatric dosing.