Like a topical medicine, a topical reference or story applies to something specific, focusing on a topic that's currently in the news. TV comedians often use topical humor, making jokes about a currently popular movie or the latest political scandal—if possible, one that just broke that same day. Treat someone to science‑backed, inclusive skincare with a Topicals gift card—simple, thoughtful self‑care for any skin journey. Topicals is transforming the way you feel about skin through effective science backed products for chronic skin conditions and mental health advocacy. Discover Topicals now at Sephora! Shop now, and pay in 4 interest-free payments later with Klarna! Define topical. topical synonyms, topical pronunciation, topical translation, English dictionary definition of topical. adj. 1. Being of current interest or relevance: topical issues. When some information or news is current and of immediate interest, we say it is topical. This might be a news story or a bit of gossip, or just a subject that is of current importance. When some information or news is current and of immediate interest, we say it is topical. This might be a news story or a bit of gossip, or just a subject that is of current importance. If it's now, it's topical. Topical refers to any medication, product, or treatment applied directly to a body surface, most commonly the skin, to produce its effects right where it’s placed. What Does Topical Mean? “Topical” is an adjective that can be used in various contexts, but broadly, it relates to topics, current events, or areas of interest. TOPICAL definition: 1. of interest at the present time; relating to things that are happening at present: 2. A topical…. Learn more.