Tramadol and acetaminophen combination is used to relieve acute pain severe enough to require an opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. When used together, the combination provides better pain relief than either medicine used alone. Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis. Tramadol is an opioid agonist that may be used to treat moderate to moderately severe chronic pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Learn about tramadol usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Tramadol ER is used to treat chronic pain that can't be managed with other pain relievers. Learn about its side effects, cost, dosage, and interactions. Find patient medical information for Tramadol (Ultram, Conzip, Qdolo) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings What is tramadol, and what is it used for? Tramadol is a synthetic (man-made) pain reliever (analgesic). Researchers and doctors do not know the exact mechanism of action of tramadol, but it is similar to morphine. Detailed Tramadol dosage information for adults, the elderly and children. Includes dosages for Pain and Chronic Pain; plus renal, liver and dialysis adjustments. Tramadol is a synthetic opioid analgesic that was first approved for medical use in the 1990s. It is commonly prescribed for conditions such as post-surgical pain, osteoarthritis, and fibromyalgia. Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain. When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence.