Tussionex is a combination of an antihistamine that blocks allergic reactions and reduces the production of mucus (chlorpheniramine), and a narcotic that relieves pain and cough (hydrocodone). Tussionex is a liquid that slowly releases the chlorpheniramine and hydrocodone after it is ingested. Hydrocodone and chlorpheniramine polistirex combination is used to treat cough and respiratory symptoms associated with a cold or allergy. Hydrocodone polistirex is an opioid cough suppressant. It acts directly on the cough center in the brain to prevent a cough. Hydrocodone/chlorpheniramine is a combination medication containing an opioid and an antihistamine. It's a prescription cough syrup for adults to temporarily relieve cough and other respiratory symptoms related to allergies or the common cold, like runny nose and sneezing. TUSSIONEX Pennkinetic Extended-Release Suspension is indicated for relief of cough and upper respiratory symptoms associated with allergy or a cold in adults and children 6 years of age and older. TUSSIONEX Pennkinetic Extended-Release Suspension is indicated for relief of cough and upper respiratory symptoms associated with allergy or a cold in adults and children 6 years of age and older. Chlorpheniramine is an antihistamine that helps to relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Opioid cough suppressants should not be used by children younger than 18 years. Children are at higher risk for serious (even fatal) side effects, especially breathing problems. Tussionex (Hydrocodone and Chlorpheniramine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Tussionex package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Tussionex PennKinetic (chlorpheniramine and hydrocodone) treats runny noses, sneezing, and cough caused by the common cold. Includes Tussionex side effects, interactions and indications. Overview: Hydrocodone/chlorpheniramine is a combination medicine taken for coughing and other symptoms like a runny nose, sneezing, and a stuffy nose from allergies or the common cold. Common side.