Compare Tylenol Arthritis Pain vs Tylenol Extra Strength head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Regular strength Tylenol typically contains 325mg of acetaminophen per tablet, while extra strength Tylenol contains 500mg per tablet. The extra strength version is often preferred for more severe joint pain, as it provides a higher dose of acetaminophen in a single tablet. Compare Tylenol vs Tylenol Arthritis Pain head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Discover the key differences between Tylenol and Tylenol Arthritis and how they affect arthritis management. Read more to choose the right option for you. The biggest distinction is that Tylenol Arthritis is an extended-release tablet designed to spread its effect over eight hours, while standard Tylenol formulations release all their acetaminophen at once and wear off in four to six hours. If you have arthritis pain and reach for a Tylenol for relief, you may be doing yourself a disservice. According to a recent study, Tylenol is only a little bit better than a placebo for treating arthritis pain in the hip or knee. Tylenol Arthritis is better suited for chronic arthritis pain because it lasts longer and requires less frequent dosing, while Tylenol Extra Strength is designed for occasional aches and pains.