Acetaminophen effectively relieved the functional limitation that occurred in the less-disabled segment of persons with migraine. As the goals of acute migraine therapy include relief of pain and restoration of the ability to function, this is an important benefit. Both acetaminophen and ibuprofen can ease headaches, but they work in slightly different ways. Acetaminophen acts primarily in the brain, where it blocks pain signals and reduces fever. This makes it helpful for mild pain and temperature control, but it doesn’t reduce inflammation. When taken according to the labeling, Tylenol is a safe and effective way to manage your migraine pain. However, it's important to remember that Tylenol now comes in various products. Only acetaminophen (Tylenol) was less helpful, helping just 37% of the time. A common combination medication containing aspirin, acetaminophen, and caffeine (sold under the brand name Excedrin) worked only slightly better than ibuprofen, or about half the time. Try TYLENOL® Ultra Relief, with 500 mg of acetaminophen and 65 mg of caffeine to relieve mild to moderate migraine & headache pain fast. Visit our website. Discover how TYLENOL® pain relieving products & medicine can help you and your family feel better. Learn about symptoms, treatments, dosages and product info. Acetaminophen is generally suitable for treating mild to moderate migraine attacks, especially when taken early before the pain becomes severe. Studies show that a 1000 mg dose can reduce pain intensity and improve functional disability. Explore all of the TYLENOL® products: Fast and effective pain relief for different types of headache pain including tough headaches and migraines. For adults with migraine, the typical acetaminophen (Tylenol) dose is 500–1,000 mg every 4 to 6 hours, with a maximum of 3,000–4,000 mg in 24 hours. Many people should stay closer to 3,000 mg daily, and those at higher risk may need to limit intake to 2,000 mg. TYLENOL ® is recommended for temporary relief from minor aches and pains due to headaches, but if you think you're having migraines or cluster headaches, or have any other questions or concerns, please consult your doctor.