IDWeek 2025 C diff Risk Factors Linked to Deaths and Infection The strongest risk factor for infection is repeated exposure to high-risk antibiotics, while risk factors for deaths include White. The strongest risk factor for infection is repeated exposure to high-risk antibiotics, while risk factors for deaths include White race and healthcare settings. Two experts at IDWeek 2020 debated the best treatment for patients with the most severe type of Clostridioides difficile infection — fulminant C diff. The discussion pitted fecal microbiota. Significant challenges stand in the way of the use of fecal microbiota transplantation for C difficile infection in the US, however. OpenBiome, which provides fecal microbiota transplantation material for US patients with severe/fulminant C difficile infection, will continue distribution until December 31. Fulminant C. Diff Infection After Cardiac Surgery This paper outlines several independent risk factors for the development of a fulminant C. difficile infection after cardiac surgery. IDWeek 2020 Fulminant C diff Debate: Fecal Transplants or Antibiotics? One expert at IDWeek says fecal microbiota transplants should be initiated before colectomy. Preventive Antibiotics Proton Pump Inhibitors First-Line Treatment Fulminant C difficile Recurrence Probiotics Final Thoughts Fulminant C diff Debate: Fecal Transplants or Antibiotics? One expert at IDWeek says fecal microbiota transplants should be initiated before colectomy. The National Institute for Health and Care Excellence (NICE) has recommended faecal microbiota transplant (FMT) as a treatment option for those with recurrent Clostridium difficile (C diff.