Wellbutrin is an antidepressant sometimes prescribed off-label for ADHD. It may be used to help manage symptoms like hyperactivity and attention deficits when traditional stimulants prove effective. Wellbutrin (bupropion) is sometimes prescribed off-label for ADHD. Learn how it works, who it helps most, side effects, and how it compares to traditional stimulant medications. When I was a kid I had an ADHD diagnosis that I was prescribed Wellbutrin for. Out of all of the stuff they were giving us in the late 90s this was the least bad experience as far as I remember. If your doctor suggested bupropion (brand name: Wellbutrin) for ADHD, you may have questions. This guide presents evidence-based information on how it works, what research shows about its effectiveness, realistic timelines, side effects, and practical considerations such as insurance. I do find that Wellbutrin helps with mood swings and helps temper the irritability that comes when my ADHD meds wear off. The crash isn’t severe as long as I’m eating small meals throughout the day. The FDA hasn’t approved Wellbutrin to treat attention deficit hyperactivity disorder (ADHD). Still, some doctors may prescribe Wellbutrin off-label to treat ADHD. Although Wellbutrin and Adderall work differently and belong to different classes of drugs, both medications can be effective for reducing symptoms of ADHD, like inattention and impulsivity. Wellbutrin is an antidepressant sometimes used off-label to treat ADHD in adults. Wellbutrin can be taken alone or with a stimulant like Adderall to help manage ADHD symptoms. Wellbutrin (bupropion) can be prescribed off-label to treat ADHD. It can help with ADHD by influencing certain chemicals in the brain, namely norepinephrine and dopamine, which play a role in attention and impulsive control. While stimulant medications are the first line of treatment, research has shown that using Wellbutrin may help to improve ADHD symptoms, including impulsivity, hyperactivity, and inattention.