WELLBUTRIN (bupropion hydrochloride) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). Bupropion is the active ingredient in Wellbutrin and Zyban, Auvelity contains bupropion and dextromethorphan, and Contrave contains bupropion and naltrexone. Bupropion improves mood regulation and nicotine cravings and, when combined with naltrexone, helps reduce food intake. The following medications may decrease the effects of bupropion: carbamazepine (Tegretol®, Equetro®), phenytoin (Dilantin®, phenobarbital, ritonavir (Norvir®), lopinavir (KaletraTM), and efavirenz (Sustiva®). Find patient medical information for Bupropion (Wellbutrin, Zyban, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Wellbutrin (bupropion) used to treat the symptoms of major depression and seasonal affective disorder. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more. What is Wellbutrin? Wellbutrin is the brand name for bupropion and the active ingredient in Wellbutrin is bupropion hydrochloride (bupropion HCl). It’s commonly used to treat major depression and seasonal affective disorder or SAD. It’s also used to aid in smoking cessation. In 1996, the US Food and Drug Administration (FDA) approved a sustained-release formulation of alcohol-resistant bupropion called Wellbutrin SR, a tablet intended to be taken twice a day (as compared with three times a day for immediate-release Wellbutrin). [195] Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder. Includes Wellbutrin side effects, interactions and indications. Bupropion is used to treat major depressive disorder (MDD) and to prevent seasonal affective disorder (SAD), which is sometimes called autumn-winter seasonal depression. It is also used as part of a support program to help people stop smoking. Bupropion is sold under different brand names. Bupropion is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation).