Memantine is an NMDA blocker whose FDA approval is as a medication to help cognitive decline in moderate-to-severe Alzheimer's disease. According to my regular/first neurologist, the literature on it in headaches is mixed. But, I have to tell you, it has given me a lot of my life back. I have tried almost every class of medication. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. I have tried most SSRI’s, a handful of antipsychotics, some SNRI’s and benzodiazepines. My current psychiatrist wants to try Memantine. I looked it up, and it is for management of dementia?? I know that medication can have some alternative uses, but has anyone here had any luck? I am afraid to try the medication myself. Memantine acts as a non-competitive antagonist at different neuronal nicotinic acetylcholine receptors (nAChRs) at potencies possibly similar to the NMDA and 5-HT3 receptors, but this is difficult to ascertain with accuracy because of the rapid desensitization of nAChR responses in these experiments. A sub for discussing all uses of Memantine, from therapeutic to recreational. Official discord: What experience do any of you have with memantine? Any noticeable side effects. My dad's on so many different medications and there have been so many changes over the last few years It's hard to keep track of everything. He's prescribed memantine twice a day. But, I did have some side effects namely sexual side effects, some weight gain, and tiredness etc. Around 6 months ago I was able to get on Memantine (Namenda) and my experience has been extremely positive. Memantine is a a super common drug in people with Alzheimer's. It is probably the most tolerated one. Overall. I have never really seen a patient with a side effect from memantine in the thousands of patients I've worked with in a memory disorder clinic. Can one use Mirtazapine and Memantine Hi all :) I want to add 10mg Memantine Morning to my 15mg Mirtazapine at night. Would it be fine? Anyone have used it together? I want to use Memantine for 2 reasons: 1. Help me with brain fog, cognition issues, mild ADHD, mild depression and even anxiety (What i read somewere) and 2. Memantine has its own tapering and withdrawal period. Unless you want to switch from a well-known drug and its side effects during withdrawal to a completely unknown drug (memantine) and try to figure it out, I would recommend not doing this.