Maximum Strength Zantac 360°® contains the FDA-approved active ingredient famotidine. Famotidine is the 1 doctor recommended active ingredient approved to both prevent and relieve heartburn* associated with acid indigestion and sour stomach. FDA Advises Consumers, Patients and Health Care Professionals After New FDA Studies Show Risk to Public Health. The U.S. Food and Drug Administration today announced it is requesting manufacturers. Ranitidine, sold under the brand name Zantac among others, is a medication used to decrease stomach acid production. [9] It is used in the treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [9] Ranitidine is used to treat and prevent ulcers in the stomach and intestines. It is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. In 2021, Zantac relaunched with a new name and different active ingredient — Zantac 360 (famotidine). Famotidine doesn't have the same cancer risk as traditional ranitidine, making it a safer option. The FDA approved a reformulated prescription-only version of ranitidine in late 2025. Maximum Strength Zantac 360° ® prevents heartburn, relieves it, and lasts up to 12 hours*, so you can enjoy the food you love! *Refers to acid control, which does not correlate to symptom relief. Shop Zantac 360 Maximum Strength Heartburn Relief Tablets and read reviews at Walgreens. Pickup & Same Day Delivery available on most store items. Learn about Zantac 360 (famotidine) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Zantac (ranitidine) was used to treat or prevent heartburn or acid reflux. It was recalled in April 2020 and replaced with Zantac 360 (famotidine). Zantac is used to treat and prevent ulcers in the stomach and intestines. Includes Zantac side effects, interactions, indications, recalls, cancer risk warnings, FDA alerts, and news updates.