In 2021, Zantac relaunched with a new name and different active ingredient — Zantac 360 (famotidine). Famotidine doesn't have the same cancer risk as traditional ranitidine, making it a safer option. The FDA approved a reformulated prescription-only version of ranitidine in late 2025. Easy-to-read patient tips for Zantac covering how it works, benefits, risks, and best practices. This Summer, Heartburn Doesn't Get a Seat at the Table. Good food, great company, zero interruptions. Zantac 360°® prevents heartburn, relieves it fast, and lasts for up to 12 hours*. Maximum Strength Zantac 360°® contains the FDA-approved active ingredient famotidine. Famotidine is the 1 doctor recommended active ingredient approved to both prevent and relieve heartburn* associated with acid indigestion and sour stomach. Zantac is used to treat and prevent ulcers in the stomach and intestines. Includes Zantac side effects, interactions, indications, recalls, cancer risk warnings, FDA alerts, and news updates. Shop Zantac 360 Maximum Strength Heartburn Relief Tablets and read reviews at Walgreens. Pickup & Same Day Delivery available on most store items. Learn about Zantac 360 (famotidine) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Zantac (ranitidine) was used to treat or prevent heartburn or acid reflux. It was recalled in April 2020 and replaced with Zantac 360 (famotidine). Ranitidine, sold under the brand name Zantac among others, is a medication used to decrease stomach acid production. [9] It is used in the treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [9] Zantac 360 Maximum Strength Heartburn Prevention and Relief Tablets, 20 mg Famotidine Pills with Targeted Relief to Control Acid Before Heartburn Starts, 50 Count (Pack of 2).