Get the best price on Zoloft at pharmacies near you with SingleCare. Save up to 80% with our Zoloft coupons - with or without insurance! Zoloft (Sertraline) - Complete Clinical and Patient Guide Author: Psychiatry & Behavioral Medicine Editorial Team Updated: October 8, 2025 Zoloft, known by its generic name sertraline hydrochloride, is one of the most frequently prescribed antidepressants in modern psychiatry. It belongs to the selective serotonin reuptake inhibitor (SSRI) class and is widely used for depression, anxiety. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Sertraline is a medication that increases the amount of serotonin hormone in your brain. It treats depression, anxiety and other mental health conditions. What is Zoloft? Zoloft is the brand name for sertraline, an antidepressant that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It's used to treat a list of mental health conditions, including anxiety and depression, by increasing serotonin levels in your brain. Find out how Zoloft is used to treat anxiety, its effectiveness, dosage, side effects, and when it may be the right option for you. Starting Zoloft? This isn’t a medical brochure — it’s honest, quiet advice from someone who’s been through it. What the first two weeks actually feel like, when relief finally shows up, and how to hold on until it does. No sugarcoating. Just support. Description Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.