Comprehensive medical guide to Zoloft (Sertraline): how it works, dosage, safety, patient experience, cost, and therapy comparisons. Learn when and how to use sertraline safely. Sertraline is a medication that increases the amount of serotonin in your brain. Serotonin is a hormone that helps regulate your mood. It treats depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and premenstrual dysphoric disorder. What is this medication? Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Zoloft (Sertraline Hcl) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. What is Zoloft? Zoloft is the brand name for sertraline, an antidepressant that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It's used to treat a list of mental health conditions, including anxiety and depression, by increasing serotonin levels in your brain. Sertraline is an antidepressant medication that works in the brain. It is approved for the treatment of unipolar major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and social anxiety disorder. Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. Starting Zoloft? This isn’t a medical brochure — it’s honest, quiet advice from someone who’s been through it. What the first two weeks actually feel like, when relief finally shows up, and how to hold on until it does. No sugarcoating. Just support.