Cannabidiol (CBD) is the main non-psychoactive phytocannabinoid derived from Cannabis sativa L. It is now an active pharmaceutical ingredient (API), given its usage in treating some types of pediatric epilepsy. For this reason, this compound. To the authors’ knowledge, this is the first case report involving the identification of THC-O-As and CBD-di-O-A in commercially available products. Minimal clinical/pharmacological data is available for these emerging synthetic cannabinoids/novel psychoactive substances. To address some of these challenges, this work describes two similar liquid chromatography tandem mass spectrometry (LC-MS/MS) methods which were developed and validated for measuring CBD and trace level controlled cannabinoids in CBD containing foods. As Δ-8 THC is a synthetic product synthesized from cannabidiol (CBD), there are valid concerns regarding the presence of impurities in these products with unknown effects on the human body. Cannabidiols (CBD) are one of the main cannabinoids produced by Cannabis sativa and has been clinically shown to reduce chronic pain and inflammation, without the intoxicating effects. Regulation has not kept pace with the growth of the hemp-derived CBD market. We have evaluated the risk of Δ9-tetrahydrocannabinol (Δ9-THC) contaminat… As Δ-8 THC is a synthetic product synthesized from cannabidiol (CBD), there are valid concerns regarding the presence of impurities in these products with unknown effects on the human body. Impurities of psychotropic cannabinoids D9-tetrahydrocannabinol (D9-THC) and D8-THC have been found in extracted CBD, thus hypothesizing a possible contamination from the plant. The reported characteristics of cannabidiol (CBD) have encouraged significant growth in commercial CBD products. There is limited information on the stability of CBD and some researchers have noted significant reductions of CBD in products. In. As D-8 THC is a synthetic product synthesized from cannabidiol (CBD), there are valid concerns regarding the presence of impurities in these products with unknown effects on the human body.