Clobetasol is a highly potent corticosteroid that helps reduce inflammation in the body. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Clobetasol is available in a cream, gel, ointment, lotion, solution, foam, or spray. Both forms are used to treat inflammation and itching from skin conditions. They’re also used to treat plaque psoriasis. Learn about side effects, warnings, dosage, and more for clobetasol cream. Overview: Topical clobetasol is used to treat skin conditions that involve inflammation and itchiness, including psoriasis. Common side effects from topical clobetasol are skin reactions, such. Clobetasol is a super potent (very strong) corticosteroid that's applied to the skin. It helps relieve skin inflammation and irritation from moderate-to-severe skin problems, like psoriasis. NHS information about clobetasol, including what it's used for, who can use it, how to use it and possible side effects. Clobetasol propionate is an ointment you can rub on your skin to treat eczema and psoriasis. It reduces swelling, redness, itching and rashes caused by these skin conditions. Clobetasol is a prescription topical steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Learn about side effects, drug interactions, dosages, warnings, and more. Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison. [2][3] Clobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. Clobetasol propionate is used cosmetically for skin whitening, although this use is controversial. The US Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the US.