While alcohol does not cause dangerous interactions with azithromycin in most cases, it can worsen side effects and delay recovery from illness. Your doctor may recommend completing treatment with azithromycin before drinking alcohol. Azithromycin is generally a safe drug. Drinking moderate amounts of alcohol (three drinks or fewer per day) doesn’t seem to reduce the effectiveness of this drug. However, combining azithromycin. Find out if Azithromycin interacts with alcohol, how it affects treatment efficacy, and the exact timing for safe consumption afterward. There is no direct drug interaction between azithromycin and alcohol, but alcohol can worsen side effects like nausea and upset stomach and may slow your recovery from infection. It is generally recommended to wait at least 24 hours after finishing azithromycin before drinking alcohol. Azithromycin does not inhibit the necessary enzyme for alcohol metabolism, meaning that a sudden chemical poisoning is not a direct concern. Moderate alcohol intake is not shown to drastically alter the pharmacokinetics of azithromycin. I have been prescribed azithromycin and I'm wondering if it's OK to drink alcohol occasionally? There are no known interactions between Azithromycin (Zithromax Z-Pak) and alcohol so you could take a glass or two if you wanted to. Azithromycin is not known to interact with alcohol. But azithromycin and alcohol can cause some similar side effects, such as diarrhea and nausea. So you may be more likely to experience these. Azithromycin and alcohol do not have a direct chemical interaction that causes severe harm, but drinking alcohol while taking Azithromycin can lead to increased side effects and potentially reduce the medication’s effectiveness. Azithromycin (Zithromax) is an antibiotic. Combining azithromycin with alcohol may not be advisable when the body is fighting an infection. It could also make side effects worse.