Overview: Topical diphenhydramine is used to treat minor skin pain, itching, burns, and rashes. It works by blocking a natural substance called histamine. Topical diphenhydramine can make your. Made with 2% diphenhydramine hydrochloride, a topical analgesic pain reliever, and 0.1% zinc acetate skin protectant, this topical cream temporarily relieves itching associated with insect bites, sunburn, scrapes, minor skin irritations, burns, cuts, and rashes due to poison ivy, oak and sumac. Benadryl (diphenhydramine)—OTC antihistamine for allergies and short-term sleep. Dosing, drowsiness, interactions, and when to prefer cetirizine instead. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Discover Benadryl creams that provide fast, effective relief from itching, pain, and irritation associated with insect bites, sunburns, poison ivy, and more. Discover topical skin, rash and pain relief with BENADRYL® Extra Strength Itch Stopping Cream for bug bites, sunburn, poison ivy rash, and other minor skin irritations. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Itchy skin relief: should you reach for Benadryl cream or hydrocortisone? GoodRx compares the two creams to help you choose the best treatment for fast relief. What symptoms does Topical BENADRYL® Itch Stopping Cream relieve? Topical BENADRYL ® Itch Stopping Cream temporarily relieves pain and itching associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes, and rashes due to poison ivy, poison oak, and poison sumac. Shop for Benadryl Cream at Walmart.com. Save money. Live better.