Available in two strengths, Depakote ER contains the same active ingredient as Depakote Tablets but it is designed to slowly deliver the medication over a 24-hour period. Drug Safety Update - Valproate medicines (Epilim, Depakote): contraindicated in women and girls of childbearing potential unless conditions of Pregnancy Prevention Programme are met. DEPAKOTE® (divalproex sodium) delayed-release tablets and DEPAKOTE® ER (divalproex sodium) extended-release tablets are prescription medicines used: DEPAKOTE ER and DEPAKOTE are also used to prevent migraine headaches. Find patient medical information for Divalproex Sodium (Depakote, Depakote ER, Depakote Sprinkles) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and. Learn about Depakote (divalproex sodium), which is a drug used to treat certain kinds of seizures and bipolar episodes and prevent migraine headaches. Divalproex sodium is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. Depakote (Depakote Divalproex Sodium Tablets) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. What is Depakote ER? Depakote ER comes in different pill forms that are for different uses. Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications. Depakote is an anti-epileptic used for manic episodes associated with bipolar disorder, certain seizure disorders and for the prevention of migraine headaches. Depakote tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. The tablets are sometimes used together with other seizure medications.