Yes, lisinopril can make you tired. Fatigue affects roughly 5-10% of people who take this ACE inhibitor, most often in the first few weeks after starting or increasing a dose. Understanding why lisinopril tiredness happens and what is normal can help you stay on track with treatment. Per the prescribing information for lisinopril, between 2% and 4% of individuals experience fatigue, and an even higher percentage experience headache and dizziness ( 5%). Lisinopril also made me tired, but to a degree that I figured I could live with. A few months later, I realized I hadn't had a headache since I'd started taking it. Though, in some cases, lisinopril can lower your blood pressure too much (hypotension). This can cause more severe fatigue, along with dizziness or even fainting. That's because you won't necessarily know your potassium levels are rising at first, but if they get high enough, they can make you feel exhausted, numb, or tingly. Lisinopril can cause side effects that range from mild to serious. The most common lisinopril side effects are dizziness, headache, a dry cough, and feeling tired. Do not use supplements or salt substitutes containing potassium without first checking with your doctor. Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.