It is used after menopause to reduce vaginal dryness, pain during sex, hot flashes, night sweats, prevent osteoporosis, and to treat advanced prostate cancer. The tablets are also used to treat. Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body. This medicine is available only with your doctor's prescription. During your reproductive years, estradiol is basically the star of the show—the most abundant and powerful of the bunch. It is produced by your ovaries (and to a smaller degree your fat cells and adrenal glands) and is responsible for regulating your menstrual cycle. Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol is a female hormone (estrogen). It is used by women to help reduce vaginal symptoms of menopause. Learn about side effects, drug interactions, dosages, warnings, and more. Estradiol (E2) is the most potent and clinically measured form of estrogen. It is produced primarily in the ovaries in women, in small amounts by the testes in men, and in fat tissue in both sexes. Estradiol can be used to help manage the symptoms of menopause. In fact, when used correctly, it can eliminate hot flashes very quickly. Find out what normal estradiol levels by age should look like, how they vary by gender, and what high or low levels might mean for your health. Estradiol levels vary by age. Learn normal estradiol levels by age with easy-to-read charts and what low estradiol means for women and men.