Trazodone is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Trazodone is an antidepressant. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Trazodone is used to treat major depressive disorder. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression. Learn about the side effects of trazodone, from common to rare, for consumers and healthcare professionals. Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Furthermore, trazodone has shown anxiolytic properties, low cardiotoxicity, and relatively mild side effects. [28] Trazodone is an antidepressant that belongs to a group of medicines called serotonin modulators. It works by increasing the amount of serotonin, a natural chemical in the brain. Trazodone is a prescription medication used to treat depression. Learn about side effects, dosages, drug interactions, warnings, and more. Find out how trazodone treats depression and anxiety and how to take it. NHS medicines information on trazodone – what it's used for, side effects, dosage and who can take it. Trazodone is an antidepressant that’s FDA approved to treat major depressive disorder (depression). It’s also commonly prescribed off-label for insomnia (trouble sleeping). Trazodone is an antidepressant that is sometimes prescribed as a sleep aid. It is not addictive and may offer additional benefits over other sleep aids for certain conditions, such as sleep apnea. Why is this medication prescribed? Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.