A GI cocktail consists of 3 different ingredients — an antacid, viscous lidocaine, and an anticholinergic called Donnatal. It’s used to treat indigestion and associated symptoms in hospital. “A GI cocktail is a mixture of medications used to relieve symptoms that cause gastrointestinal discomfort, such as heartburn, indigestion, or nausea,” says Matthew Hoscheit, M.D., a. A GI cocktail is a combination of an antacid, viscous lidocaine, and an anticholinergic (Donnatal) used in hospital and emergency settings to treat indigestion and related symptoms. The core idea behind a GI cocktail is to combine ingredients that address multiple facets of digestive distress. Typically, it aims to neutralize stomach acid, reduce spasms, and provide a soothing, coating effect on the stomach lining. A GI cocktail is a liquid medication mixture for indigestion, combining antacids, viscous lidocaine, and anticholinergics. Discover what exactly is a GI cocktail and its use in emergency settings. What is a GI cocktail and how does it help with Acid Reflux? A GI cocktail is a mixture of 3 different types of medications that help with pain related to GERD and gastritis. The standard GI cocktail consists of liquid antacid alone, as research shows that adding other components provides no additional benefit for symptom relief. A GI cocktail is a mixture of liquid medications given in the emergency department to quickly relieve upper digestive pain, particularly the burning, gnawing discomfort of dyspepsia (indigestion) or acid reflux flare-ups. The GI cocktail does not refer to a specific product. Rather, it refers to a mixture of viscous lidocaine, an antacid, and an anticholinergic. [1][2] Viscous lidocaine works as an anesthetic to numb pain in the throat, esophagus, and stomach. A GI cocktail is a mix of meds used to relieve indigestion, chest pain, and GI discomfort. Learn how it works, its ingredients, uses, and possible side effects.