What is a GI cocktail and how does it work? Learn about this fast-acting stomach relief treatment, its ingredients, when to use it, and what to expect. “A GI cocktail is a mixture of medications used to relieve symptoms that cause gastrointestinal discomfort, such as heartburn, indigestion, or nausea,” says Matthew Hoscheit, M.D., a. The standard GI cocktail consists of liquid antacid alone, as research shows that adding other components provides no additional benefit for symptom relief. A gastrointestinal (GI) cocktail is a mixture of medications used to treat indigestion (dyspepsia), as well as symptoms of gastrointestinal problems such as chest and belly pain. A gastrointestinal (GI) cocktail is a mixture of medications that you can drink to help ease the symptoms of indigestion. A GI cocktail is a mixture of liquid antacid, viscous lidocaine, and an anticholinergic drug. Also known as the 'green lizard', a GI cocktail is used to treat dyspepsia. A GI cocktail is a facility-specific mixture used for dyspepsia, reflux-like pain, gastritis symptoms, or suspected esophageal irritation. It traditionally includes an antacid, sometimes viscous lidocaine, and sometimes an antispasmodic or anticholinergic medication. A GI cocktail is a combination of an antacid, viscous lidocaine, and an anticholinergic (Donnatal) used in hospital and emergency settings to treat indigestion and related symptoms. The GI cocktail does not refer to a specific product. Rather, it refers to a mixture of viscous lidocaine, an antacid, and an anticholinergic. [1][2] Viscous lidocaine works as an anesthetic to numb pain in the throat, esophagus, and stomach. Use of lidocaine in the gastrointestinal cocktail for the treatment of dyspepsia. The standard GI cocktail consists of 30 mL of liquid antacid (such as Maalox) combined with 10 mL of viscous lidocaine 2% and 10 mL of an anticholinergic age.