A GI cocktail consists of 3 different ingredients — an antacid, viscous lidocaine, and an anticholinergic called Donnatal. It’s used to treat indigestion and associated symptoms in hospital. The standard GI cocktail consists of liquid antacid alone, as research shows that adding other components provides no additional benefit for symptom relief. “A GI cocktail is a mixture of medications used to relieve symptoms that cause gastrointestinal discomfort, such as heartburn, indigestion, or nausea,” says Matthew Hoscheit, M.D., a. A GI cocktail is a combination of an antacid, viscous lidocaine, and an anticholinergic (Donnatal) used in hospital and emergency settings to treat indigestion and related symptoms. The standard GI cocktail consists of 30 mL liquid antacid (aluminum/magnesium hydroxide) plus 15 mL of 2% viscous lidocaine, with optional addition of 10 mL. A gastrointestinal (GI) cocktail is a mixture of medications used to treat indigestion (dyspepsia), as well as symptoms of gastrointestinal problems such as chest and belly pain. A GI cocktail is a mix of medicines used to relieve indigestion-like chest or upper abdominal discomfort, but it does not diagnose the cause. A GI cocktail is a mixture of liquid antacid, viscous lidocaine, and an anticholinergic drug. Also known as the 'green lizard', a GI cocktail is used to treat dyspepsia. A GI cocktail is a facility-specific mixture used for dyspepsia, reflux-like pain, gastritis symptoms, or suspected esophageal irritation. It traditionally includes an antacid, sometimes viscous lidocaine, and sometimes an antispasmodic or anticholinergic medication. The GI cocktail does not refer to a specific product. Rather, it refers to a mixture of viscous lidocaine, an antacid, and an anticholinergic. [1][2] Viscous lidocaine works as an anesthetic to numb pain in the throat, esophagus, and stomach.