See Implementation and effectiveness of intermittent preventive treatment in school aged children using dihydroartemisinin-piperaquine to reduce malaria burden: an implementation research of a cluster randomised trial in Tanzania , 103628. The World Health Organization (WHO) has recommended several malaria chemoprevention strategies, some of them for over a decade, and each with documented efficacy and cost effectiveness. In 2022, the WHO updated and augmented its malaria chemoprevention guidelines to facilitate their wider use. Despite this burden, SAC are often excluded from malaria-targeted interventions and act as a key reservoir for transmission. Intermittent Preventive Treatment for school-aged children (IPTsc), recommended by the World Health Organization (WHO), involves administering a full antimalarial treatment course at regular intervals to prevent infection. Large scale implementation of IPTsc achieved impact comparable to randomised trials and was operationally feasible and well accepted by communities and teachers. This study sets a benchmark for school-based malaria chemoprevention in Tanzania and provides groundwork for national policy adoption. Intermittent preventive treatment (IPT) of school-aged children with antimalarial drugs decreases rates of infection, anaemia, and clinical malaria. Since school-aged children are a major transmission reservoir, we estimated the effect of IPT for this group on Plasmodium falciparum transmission to younger children and adults across three epidemiological settings. Malaria remains a leading cause of childhood morbidity and mortality in sub-Saharan Africa, particularly among children under 5 years of age. To help address this challenge, the WHO recommends chemoprevention for certain populations. For children. National malaria programmes can consider IPTsc if resources allow for its introduction among school-aged children without compromising chemoprevention interventions for those carrying the highest burden of severe disease, such as children 5 years old. National malaria control programmes have adopted and implemented chemoprevention strategies for young children over the past decade, and for even longer for pregnant women. In 2020, WHO convened a group of leading malaria experts to consider more than 10 years of evidence and operational experience on these interventions. Malaria remains a major public health challenge in sub-Saharan Africa, with school-aged children (SAC) increasingly recognized as a high-risk group due to asymptomatic infections that sustain transmission. In Tanzania, where malaria prevalence. Mixed design methods were used to assess the feasibility and acceptability of implementing IPTsc as part of a more comprehensive health package for schoolchildren. The study reimagined an existing school health programme for Neglected Tropical Diseases (NTD) control include IPTsc implementation. Promoting malaria chemoprevention Preventive chemotherapy is the use of medicines, either alone or in combination, to prevent malaria infection and its consequences.