Tylenol (acetaminophen) PM: Is not an NSAID and could probably be used. However, Tylenol is not an NSAID. Tylenol is the brand name for the drug acetaminophen, and it works by disrupting pain signals in the body. NSAIDs alleviate pain while reducing inflammation. TYLENOL® PM contains acetaminophen (not an NSAID, like ibuprofen or naproxen) as its pain reliever and diphenhydramine HCl as its sleep aid. Key Takeaways Tylenol (acetaminophen) helps reduce pain and fever but does not reduce inflammation. NSAIDs like Advil (ibuprofen) and Aleve (naproxen sodium) help reduce pain and inflammation, making them better for injuries. Side effects, including increased risk of stroke, occur with some NSAIDs. Tylenol PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains. Tylenol PM is not for use in treating sleeplessness without pain, or sleep problems that occur often. Is Tylenol an NSAID? No. Tylenol is acetaminophen, a different pain reliever that reduces pain and fever but does not work like NSAIDs. No, acetaminophen (Tylenol) is not classified as an NSAID (nonsteroidal anti-inflammatory drug). Acetaminophen is classified as a miscellaneous analgesic for mild to moderate pain and fever. Tylenol is not an NSAID. Tylenol’s active ingredient, acetaminophen, belongs to a separate class of medications called analgesics and antipyretics, meaning it relieves pain and reduces fever. Tylenol (acetaminophen) is not a nonsteroidal anti-inflammatory drug (NSAID), but it is an over-the-counter analgesic. Both Tylenol and NSAIDs can reduce pain and fevers, but Tylenol does not have the anti-inflammatory and antiplatelet effects that NSAIDs have. Acetaminophen vs. Ibuprofen: Which to Use? If you're confused which to use, experts generally advise you to choose ibuprofen for inflammation and acetaminophen for just pain.