Lidocaine toxicity can cause sickness and dizziness and can be life threatening in severe cases. Learn more about lidocaine overdose. Lidocaine Toxicity - SAMS mnemonic for symptoms, effects on the cardiovascular and nervous system, complications like seizures and cardiac arrest. Local anesthetic systemic toxicity (LAST) is a rare, life-threatening complication of receiving local anesthetic medications. LAST typically causes issues with your central nervous system and/or cardiovascular system, like seizures and arrhythmias. While uncommon, a lidocaine overdose is a serious medical issue. Learn more about how an overdose happens, symptoms, and what to do if you’ve received too much lidocaine. Local anesthetic systemic toxicity: current perspectives. Local Reg Anesth. 2018 Aug 8;11:35-44. doi: 10.2147/LRA.S154512 [PubMed] 31461049 Gitman M, Fettiplace MR, Weinberg GL, Neal JM, Barrington MJ. Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis, and Management. Local anesthetic systemic toxicity is a serious condition that can occur after administration of local anesthetics. Despite its widespread use, most physicians are not familiar with the life-threatening manifestations of lidocaine toxicity and its treatment. Our case demonstrates a successful resuscitation after cardiac arrest in a healthy 33-year-old female with systemic lidocaine toxicity after she received lidocaine as a local anesthetic. Local Anaesthetic Toxicity- sodium channel blockade - arrhythmias and neurotoxicity Lidocaine is a widely used medication, serving as both a local anesthetic to numb specific body areas and an antiarrhythmic agent for irregular heart rhythms. Understanding potential adverse reactions, such as lidocaine toxicity, is important for patient well-being. This article explains what lidocaine toxicity involves, its causes, how to recognize its signs, and its management and prevention. Lidocaine toxicity refers to the harmful effects that can occur when high levels of lidocaine are present in the blood. It can cause injury to muscles and nerves at the injection site, as well as harmful effects involving the brain or heart muscle. Overdose at the application site can lead to alarming reactions such as total numbness of the spinal cord or unintentional entry into the layer.