Get clear safety guidance for Lisinopril and hydrochlorothiazide, including warnings, precautions, when to seek medical assistance, and how to use it correctly. The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the. What is this medication? LISINOPRIL; HYDROCHLOROTHIAZIDE (lyse IN oh pril; hye droe klor oh THYE a zide) treats high blood pressure. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. This medication is a combination of an ACE inhibitor and diuretic. Find patient medical information for Lisinopril/Hydrochlorothiazide (Prinzide, Zestoretic) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Lisinopril/HCTZ is usually only prescribed after you’ve successfully taken lisinopril and HCTZ individually. The starting dosage of lisinopril/HCTZ is 10 mg/12.5 mg or 20 mg/12.5 mg by mouth once daily. Hydrochlorothiazide and lisinopril: side effects, dosage, interactions, FAQs, reviews. Used for: heart failure, high blood pressure The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Description Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering. Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. [2][3] Typically, it becomes an option once a person is doing well on the individual components. [4] It is taken by mouth. [3.