Lisinopril and hydrochlorothiazide (Zestoretic, Prinzide) is a combination of two drugs, lisinopril and hydrochlorothiazide, and is prescribed to treat hypertension (high blood pressure). Lisinopril and Hydrochlorothiazide: learn about side effects, dosage, special precautions, and more on MedlinePlus Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Find patient medical information for Lisinopril/Hydrochlorothiazide (Prinzide, Zestoretic) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. When pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] Get clear safety guidance for Lisinopril and hydrochlorothiazide, including warnings, precautions, when to seek medical assistance, and how to use it correctly. Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Lisinopril/HCTZ is usually only prescribed after you’ve successfully taken lisinopril and HCTZ individually. Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings.