Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings. Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Lisinopril/HCTZ is usually only prescribed after you’ve successfully taken lisinopril and HCTZ individually. Lisinopril and Hydrochlorothiazide: learn about side effects, dosage, special precautions, and more on MedlinePlus Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] LISINOPRIL; HYDROCHLOROTHIAZIDE (lyse IN oh pril; hye droe klor oh THYE a zide) treats high blood pressure. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. This medication is a combination of an ACE inhibitor and diuretic. Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Find patient medical information for Lisinopril/Hydrochlorothiazide (Prinzide, Zestoretic) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. Learn about the side effects of hydrochlorothiazide/lisinopril, from common to rare, for consumers and healthcare professionals. Lisinopril/hydrochlorothiazide (Zestoretic) is an oral medication used to treat high blood pressure. Learn about side effects, warnings, dosage, and more.