Second Line therapy and can be administered sublingually, orally, vaginally, and rectally. [1] The following table is automatically generated from disease/condition pages across WikEM. ↑ Mousa HA, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2003; (1):CD003249. CYTOTEC® (misoprostol) medication page for healthcare professionals to search for scientific information on Pfizer medications. Also find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Find patient medical information for Misoprostol (Cytotec) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings There are currently multiple dedicated Misoprostol products on the global medication market. A list and detailed map can be accessed by clicking the link below. Misoprostol by mouth is the least effective treatment for producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Misoprostol is a synthetic prostaglandin that works by replacing prostaglandins whose production is blocked by aspirin or NSAIDs. It is used to prevent stomach ulcers from developing during treatment with aspirin or an NSAID. Misoprostol is a synthetic prostaglandin E 1 analogue marketed as an oral preparation used to prevent and treat gastroduodenal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs). Misoprostol is used to decrease the risk of having stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin. This medicine works by helping the stomach protect itself against acid damage, and decreases the amount of acid produced by the stomach. In normal volunteers, Cytotec (misoprostol) is rapidly absorbed after oral administration with a Tmax of misoprostol acid of 12 ± 3 minutes and a terminal half-life of 20–40 minutes. Misoprostol is a very powerful stimulator of uterine contractions in late pregnancy and can cause fetal death and uterine rupture if used in high doses. Follow the dosage regimes carefully and do not exceed those doses.