Omeprazole is a proton pump inhibitor that is used to treat symptoms of gastroesophageal reflux disease and other conditions caused by excess stomach acid. Omeprazole is a medication that reduces the amount of acid in your stomach. It treats heartburn, stomach ulcers and reflux disease. Learn the warning signs and how to protect yourself. If you've been taking omeprazole (Prilosec), esomeprazole (Nexium), or another proton pump inhibitor (PPI) for acid reflux or heartburn, you may not realize there's a hidden cost to long-term use: magnesium depletion. Omeprazole Magnesium Granules package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. An article published in 2013 claims that the long-term use of PPIs is associated with decreased calcium absorption (causing increased risk of osteoporosis and fractures), decreased magnesium absorption (causing electrolyte disturbances), and increased risk of certain infections, such as C. difficile and community-acquired pneumonia. In general, it seems that the longer you take omeprazole and the higher your dosage, the greater your risk of developing low magnesium levels. If you take other medications that lower magnesium, such as digoxin (Lanoxin), you may be more prone to this omeprazole side effect. Yes, you can take magnesium supplements while using omeprazole. However, careful timing is important to ensure proper absorption and avoid potential side effects. Omeprazole can cause low magnesium levels, also known as hypomagnesemia, which can be serious. Decreased magnesium levels can cause seizures or heart rhythm problems. It is used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. Because there is a salt (magnesium) attached to the Omeprazole, it makes it easy to dissolve and can be taken on an empty stomach or with food. Whenever Omeprazole alone is taken, it should be taken prior to meals.