Find patient medical information for Oxycodone/Acetaminophen (Percocet, Tylox, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. Oxycodone and acetaminophen tablets are used to manage pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate, and when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Generic oxycodone/acetaminophen is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Get Oxycodone/Acetaminophen for as low as $17.12, which is 86% off the average retail price of $119.12 for the most common version, by using a GoodRx coupon. Oxycodone/acetaminophen is a combination pain -relief (analgesic) medication prescribed to treat acute moderate-to-severe pain. Oxycodone is an opioid analgesic, while acetaminophen is a nonopioid drug that reduces pain and fever. Oxycodone acetaminophen is a prescription drug used for the management of moderate to severe pain. Learn about side effects, dosages, drug interactions, and more. Includes Oxycodone and Acetaminophen indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. This combination medication is used to help relieve moderate to severe pain. It contains an opioid pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong opioid pain medicines. Taking oxycodone and acetaminophen tablets with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. Detailed Acetaminophen / Oxycodone dosage information for adults. Includes dosages for Pain; plus renal, liver and dialysis adjustments.