Peyronie's disease occurs when a buildup of scar tissue causes curved and often painful erections. Learn the symptoms, causes, and treatment options. From injections and traction to surgery, here’s what actually works for Peyronie’s disease and how to choose the right treatment for your situation. Peyronie’s disease is a buildup of scar tissue on the penis, causing it to bend or curve during erections. This scar tissue interferes with the flexibility and stretching of the tissues in the penis, which results in a bent penis. Learn about Peyronie’s disease, the causes, how it develops, the risk factors, diagnosis, and treatment options, and clinical trials. Peyronie’s disease causes your penis to curve due to plaque build-up under your skin. You can treat this condition with injections, oral medications, and, in severe cases, surgery. Peyronie's disease (PD) is a benign, acquired penile connective tissue disease characterized by the occurrence of fibrotic plaques within the tunica albuginea —the dense elastic covering of the corpora cavernosa. Peyronie’s disease is a condition in which scar tissue causes a curve that affects the length and girth of your penis. There are surgical and nonsurgical treatments. Peyronie Disease - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version. If you have Peyronie's disease symptoms, you're likely to start by seeing your family doctor or general practitioner. You might be referred to a specialist in male sexual disorders called a urologist. Peyronie's (pay-roe-NEEZ) disease is a condition in which fibrous scar tissue forms in the deeper tissues under the skin of the penis. This causes curved, painful erections. It also can make the penis shorter while erect. Peyronie's disease is not caused by cancer. Penises vary in shape and size.