Comprehensive guide on diagnosing and managing Peyronie's disease, a fibrotic disorder causing penile deformity, pain, and potential erectile dysfunction. Learn about Peyronie’s disease, the causes, how it develops, the risk factors, diagnosis, and treatment options, and clinical trials. Peyronie's disease causes the penis to appear significantly curved or bent when erect. Injections, oral medications, and surgery can treat this condition. Peyronie’s disease is a connective tissue disorder of the penis that can be likened to Dupuytren’s contracture of the hand. It is characterized by the triad of bent erections, pain in the penis with erections and palpable penile plaque. Peyronie’s disease is quite common, affecting as many as one in 11 men, despite the lack of public awareness. The penis is composed of the same. The purpose of this guideline is to provide a clinical framework for the diagnosis and treatment of Peyronie's disease (PD). Peyronie's disease is a condition in which scar tissue in the penis causes the penis to bend. WebMD looks at its causes, symptoms, and treatment. Overview Peyronie's (pay-roe-NEEZ) disease is a condition in which fibrous scar tissue forms in the deeper tissues under the skin of the penis. This causes curved, painful erections. It also can make the penis shorter while erect. Peyronie's disease is not caused by cancer. Penises vary in shape and size. So having a curved erection isn't always a cause for concern. But Peyronie's disease. Peyronie’s disease is a condition in which scar tissue causes your penis to curve or lose length or girth. In some cases, it can cause pain and make it difficult or impossible for you to have sex. Causes may include an injury to your penis or a connective tissue disorder. A healthcare provider can diagnose and treat Peyronie’s disease. Peyronie's disease (PD) is a benign, acquired penile connective tissue disease characterized by the occurrence of fibrotic plaques within the tunica albuginea — the dense elastic covering of the corpora cavernosa. Peyronie's disease occurs when a buildup of scar tissue causes curved and often painful erections. Learn the symptoms, causes, and treatment options.