Seroquel XR is a prescription medicine used to treat the symptoms of Schizophrenia and Bipolar Disorder, for maintenance, mania and depressive episodes and Major Depressive Disorder. Seroquel XR may be used alone or with other medications. Seroquel XR belongs to a class of drugs called Antipsychotics, 2nd Generation; Antimanic Agents. Seroquel XR (quetiapine fumarate extended-release) is one of the most widely used psychiatric medications in the world. Medscape - Schizophrenia, bipolar disorder-specific dosing for Seroquel, Seroquel XR (quetiapine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. The information below is derived from a clinical trial database for SEROQUEL XR consisting of approximately 3400 patients exposed to SEROQUEL XR for the treatment of Schizophrenia, Bipolar Disorder, and Major Depressive Disorder in placebo-controlled trials. Seroquel XR is used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel XR is used alone or in combination with divalproex or lithium to treat manic episodes in adults with bipolar disorder. Find patient medical information for Quetiapine (Seroquel) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings SEROQUEL XR is a once-daily tablet approved in adults for add-on treatment to antidepressants for patients with major depressive disorder (MDD) who did not have an adequate response to antidepressant therapy; SEROQUEL XR is indicated for the acute treatment of manic or mixed episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex. Quetiapine is one of only two antipsychotics (the other is cariprazine) that produce equal efficacy as standalone therapies for mixed manic-depressive mood swings as they do in combination with an SSRI antidepressant. Seroquel extended release is used in combination with antidepressant medications to treat major depressive disorder in adults. Seroquel tablets may be used as part of a treatment program to treat bipolar disorder and schizophrenia in children and teenagers.