SYSTEMIC definition: 1. A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant…. Learn more. Systemic refers to something that affects an entire system, like lack of transparency in a governing body. Systematic refers to an attribute of a process itself, specifically, that it is machine-like in its efficiency and organization. Systematic and systemic both come from system. Systematic is the more common word; it most often describes something that is done according to a system or method. Systemic describes what relates to or affects an entire system, be that system physical, organizational, or societal. The simple definition of SYSTEMIC is of or relating to an entire system. Systemic – born out of a deep desire to bring our vision to life, to create something authentic and to craft pieces that embody timelessness and individuality. Systemic means affecting the whole of something. The economy is locked in a systemic crisis. This disambiguation page lists articles associated with the title Systemic. If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article. Systemic refers to something that is prevalent throughout or affecting the whole system or body. It can be used in various contexts like biology, medicine, sociology, or politics, indicating a widespread issue or condition impacting an entire organism, organization, or society, rather than isolated parts. SYSTEMIC definition: of or relating to a system, especially when affecting the entirety of a thing. See examples of systemic used in a sentence. “Systemic” means affecting the entire body rather than a single spot. In medicine, a systemic condition, treatment, or reaction is one that travels through your bloodstream and reaches tissues and organs throughout your body, as opposed to staying in one localized area.