SYSTEMIC definition: of or relating to a system, especially when affecting the entirety of a thing. See examples of systemic used in a sentence. Definition of systemic in the Definitions.net dictionary. Meaning of systemic. What does systemic mean? Information and translations of systemic in the most comprehensive dictionary definitions resource on the web. Systemic effect, an adverse effect of an exposure that affects the body as a whole, rather than one part Systemic inflammatory response syndrome, an inflammatory state affecting the whole body, frequently in response to infection Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body Something that's systemic affects all parts of something. If every dog at doggy daycare has fleas, it's a systemic problem. SYSTEMIC definition: 1. A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant…. Learn more. Systemic – born out of a deep desire to bring our vision to life, to create something authentic and to craft pieces that embody timelessness and individuality. The words systemic and systematic are both adjectives that come from the noun system. While they can each be used to broadly mean relating to a system, their usual jobs are distinct. 'Systematic' Meaning and Usage Systematic is the more common of the pair. In current English, it is most often used to describe something that uses or applies a careful system or method, or that is done. The meaning of SYSTEMIC is of, relating to, or common to a system. How to use systemic in a sentence. Systematic and Systemic: Usage Guide Define systemic. systemic synonyms, systemic pronunciation, systemic translation, English dictionary definition of systemic. adj. 1. Of or relating to systems or a system. 2. a. Relating to or affecting the entire body or an entire organism: systemic symptoms; a systemic poison. Systemic sclerosis (scleroderma) causes widespread skin thickening and can involve the lungs, kidneys, and esophagus. Infections can also be systemic. A urinary tract infection is localized. But when bacteria from that infection enter the bloodstream and trigger a body-wide response, the problem becomes systemic. This is what happens in sepsis.