What are the most common side effects of ursodiol? The most common side effects of ursodiol are listed below. Tell your healthcare provider if you have any of these side effects. Keep taking it even if your symptoms disappear. The most common side effects of Ursodiol 300mg Tablet are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them or they do not go away, let your doctor know. Common side effects of ursodiol may include: upset stomach, nausea, vomiting; diarrhea, constipation; cough, sore throat; painful urination; hair loss; or back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Learn about ursodiol (Actigall) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Learn about the side effects of ursodiol, from common to rare, for consumers and healthcare professionals. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Our Urso (ursodiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. It is generally well tolerated, with digestive side effects being the most common. Take it exactly as prescribed, and let your doctor know about any other medications you take, since some common drugs can reduce how well ursodiol works.