Vicodin is a combination medication that contains hydrocodone (an opioid) and acetaminophen (an analgesic). It's used to manage pain for people who haven't gotten enough relief from non-opioid medications. Thus, Vicodin and Vicodin ES are brand names of the said generic drug. There are no major differences except for a few details. Vicodin is available in 5mg/500mg dosages while Vicodin ES is available in 7.5mg/750mg dosages. Detailed dosage guidelines and administration information for Vicodin ES (acetaminophen and hydrocodone bitartrate). Includes dose adjustments, warnings and precautions. Vicodin ES package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Medscape - Indication-specific dosing for Vicodin, Lorcet, Hycet, Norco, Lortab Elixir, Anexsia, Vicodin ES, Vicodin HP, Xodol, Zamicet (hydrocodone, acetaminophen), frequency-based adverse. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. See also Warning section. Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Take Vicodin exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed. Take your prescribed dose every four to six hours as needed for pain. Do not take more than your prescribed dose. It reduces fever through its action on the temperature-regulating center of the brain. Frequently, hydrocodone and acetaminophen are combined to achieve pain relief, as in Vicodin and Lortab. The FDA approved Vicodin in January 1983. Vicodin ES (Hydrocodone Bitartrate and Acetaminophen) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.