What is Vicodin ES? Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. The combination of acetaminophen and hydrocodone is used to relieve moderate to severe pain. Vicodin (hidrocodona/paracetamol) es una combinación de dosis fija que consiste en el opioide hidrocodona y el analgésico no opioide paracetamol. Vicodin is a combination medication that contains hydrocodone (an opioid) and acetaminophen (an analgesic). It's used to manage pain for people who haven't gotten enough relief from non-opioid medications. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. See also Warning section. Vicodin ES package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Detailed dosage guidelines and administration information for Vicodin ES (acetaminophen and hydrocodone bitartrate). Includes dose adjustments, warnings and precautions. Vicodin is: A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage pain severe enough to require an opioid pain medicine, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them. Thus, Vicodin and Vicodin ES are brand names of the said generic drug. There are no major differences except for a few details. Vicodin is available in 5mg/500mg dosages while Vicodin ES is available in 7.5mg/750mg dosages. Vicodin ES (Hydrocodone Bitartrate and Acetaminophen) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Medscape - Indication-specific dosing for Vicodin, Lorcet, Hycet, Norco, Lortab Elixir, Anexsia, Vicodin ES, Vicodin HP, Xodol, Zamicet (hydrocodone, acetaminophen), frequency-based adverse.