Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft (sertraline), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. Sertraline is available in several dosage forms, including a capsule, tablet, or liquid that you take by mouth. The typical starting dose of Zoloft for adults with major depressive disorder (depression) is 50 mg taken once daily. If necessary, your doctor may increase your dose by 25 to 50 mg at a time. Detailed Sertraline dosage information for adults and children. Includes dosages for Depression, Panic Disorder, Post Traumatic Stress Disorder and more; plus renal, liver and dialysis adjustments. Comprehensive Zoloft (sertraline) dosage guide: starting doses, titration schedules, maximums for depression, anxiety, OCD, PTSD, PMDD, pediatric/elderly adjustments, side effects at 50mg/100mg, and safety tips from FDA-approved data. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of 25 mg or 50 mg per day is the initial. Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) used to treat several mental health conditions. A typical starting dose of Zoloft is 25 to 50 mg once daily for most conditions but can be higher if needed. Detailed dosage guidelines and administration information for Zoloft (sertraline hydrochloride). Includes dose adjustments, warnings and precautions. Dosing of Zoloft varies by condition and other factors, with dosage often starting at 25 milligrams (mg) or 50 mg once per day. Doctors adjust dosage based on a person’s specific needs. The. While 200 mg/day is the maximum recommended dose for most indications, it's worth noting that the optimal balance between efficacy and tolerability for most patients with depression is often achieved at the starting dose of 50 mg/day 2.