Detailed dosage guidelines and administration information for Zoloft (sertraline hydrochloride). Includes dose adjustments, warnings and precautions. Sertraline (Zoloft) is a first-line SSRI for depression, OCD, PTSD, and anxiety. Learn dosing, side effects, real patient reviews, and global pricing. Sertraline is available in several dosage forms, including a capsule, tablet, or liquid that you take by mouth. The typical starting dose of Zoloft for adults with major depressive disorder (depression) is 50 mg taken once daily. If necessary, your doctor may increase your dose by 25 to 50 mg at a time. Comprehensive medical guide to Zoloft (Sertraline): how it works, dosage, safety, patient experience, cost, and therapy comparisons. Learn when and how to use sertraline safely. Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft (sertraline), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. While 200 mg/day is the maximum recommended dose for most indications, it's worth noting that the optimal balance between efficacy and tolerability for most patients with depression is often achieved at the starting dose of 50 mg/day 2. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day throughout your menstrual cycle or 100 mg per day if you are only taking it during your premenstrual time. Children—Use and dose must be determined by your doctor. Starting Zoloft? This isn’t a medical brochure — it’s honest, quiet advice from someone who’s been through it. What the first two weeks actually feel like, when relief finally shows up, and how to hold on until it does. No sugarcoating. Just support. Dosing of Zoloft varies by condition and other factors, with dosage often starting at 25 milligrams (mg) or 50 mg once per day. Doctors adjust dosage based on a person’s specific needs. The.