The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of 25 mg or 50 mg per day is the initial. Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) used to treat several mental health conditions. A typical starting dose of Zoloft is 25 to 50 mg once daily for most conditions but can be higher if needed. Zoloft is commonly used to treat depression, anxiety, panic attacks and other mood disorders. Doses should be stopped slowly to help prevent withdrawal symptoms. While 200 mg/day is the maximum recommended dose for most indications, it's worth noting that the optimal balance between efficacy and tolerability for most patients with depression is often achieved at the starting dose of 50 mg/day 2. Dosing of Zoloft varies by condition and other factors, with dosage often starting at 25 milligrams (mg) or 50 mg once per day. Doctors adjust dosage based on a person’s specific needs. The. Sertraline is available in several dosage forms, including a capsule, tablet, or liquid that you take by mouth. Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft (sertraline), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day throughout your menstrual cycle or 100 mg per day if you are only taking it during your premenstrual time. Children—Use and dose must be determined by your doctor. Detailed dosage guidelines and administration information for Zoloft (sertraline hydrochloride). Includes dose adjustments, warnings and precautions. The typical starting dose of Zoloft for adults with major depressive disorder (depression) is 50 mg taken once daily. If necessary, your doctor may increase your dose by 25 to 50 mg at a time.