Estradiol vaginal gel, insert, and ring are used to treat changes in and around the vagina (eg, vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. Vaginal estrogen cream treats the symptoms of menopause that impact the vagina and female urinary tract such as vaginal dryness, burning with urination, recurrent urinary tract infections, and itching of the vaginal area. It may also reduce urinary urgency, particularly at nighttime. Systemic absorption may occur with the use of ESTRACE (estradiol vaginal cream USP 0.01%). The warnings, precautions, and adverse reactions associated with oral estrogen treatment should be taken into account. Estrace is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, and to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Estradiol (Estrace) vaginal cream is used to lessen certain symptoms related to menopause, such as vaginal itching and dryness. It's a hormone replacement therapy that's made of estradiol, a form of estrogen. ESTRACE Vaginal Cream is a cream that you place in your vagina with the applicator provided with the cream. Take the dose recommended by your healthcare provider and talk to them about how well that dose is working for you. Detailed dosage guidelines and administration information for Estrace (estradiol). Includes dose adjustments, warnings and precautions. Estrace (Estradiol) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Estrace Vaginal Cream is a prescription medication containing estradiol, a form of estrogen. It is primarily used to treat symptoms of vaginal atrophy caused by menopause, such as dryness, itching, and painful intercourse.