Zegerid (omeprazole / sodium bicarbonate) is a combination medication used to treat conditions related to having too much stomach acid. This medication is typically taken by mouth once daily. Zegerid OTC (omeprazole and sodium bicarbonate) is used to treat episodes of frequent heartburn. Includes Zegerid OTC side effects, interactions and indications. Zegerid (Omeprazole, Sodium Bicarbonate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ZEGERID Capsules and Powder for Oral Suspension are immediate-release formulations that contain sodium bicarbonate which raises the gastric pH and thus protects omeprazole from acid degradation. ZEGERID Powder for Oral Suspension is a white, flavored powder packaged in unit-dose packets. Each packet contains either 20 mg or 40 mg omeprazole and 1680 mg sodium bicarbonate. Zegerid OTC Acid Reducer increases absorption of its active ingredient, Omeprazole, to quickly alleviate painful symptoms caused by frequent heartburn. When taken as recommended, Zegerid OTC Acid Reducer gently and effectively calms stomach acid and helps to prevent heartburn and acid reflux. Zegerid OTC® is the only 24-hour frequent heartburn treatment that contains two active ingredients: the leading prescription acid reducer (omeprazole), plus a second ingredient (sodium bicarbonate) that protects the omeprazole from acid in the stomach — so it can be absorbed by the body and get right to work treating frequent heartburn. Zegerid is used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). Zegerid is also used to treat certain type of ulcers, or to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Zegerid OTC acid reflux medicine provides 24-hour protection from burning discomfort when taken once daily before eating. Each capsule contains a proton pump inhibitor (PPI) clinically proven to reduce acid at the source. ZEGERID capsules and ZEGERID for oral suspension are immediate-release formulations that contain sodium bicarbonate which raises the gastric pH and thus protects omeprazole from acid degradation.