Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol vaginal gel, insert, and ring are used to treat changes in and around the vagina (eg, vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is a synthetic (man-made) form of estrogen hormone that works by replacing declining natural estrogen levels, particularly after menopause. Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body. This medicine is available only with your doctor's prescription. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Find out what normal estradiol levels by age should look like, how they vary by gender, and what high or low levels might mean for your health. Learn about estradiol levels, their role in hormonal health, and how an estradiol blood test can diagnose imbalances. Find out normal ranges, symptoms, and treatment options. Estradiol (E2) is the most potent and clinically measured form of estrogen. It is produced primarily in the ovaries in women, in small amounts by the testes in men, and in fat tissue in both sexes. Estradiol (Estrace, Vivelle-Dot, Climara) is a moderately priced drug used to treat hot flashes and osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.