What is Estradiol Norethindrone? A Closer Look Estradiol norethindrone is a combination hormone replacement therapy (HRT) containing estradiol (an estrogen) and norethindrone (a progestin), primarily used to alleviate moderate to severe menopausal symptoms and prevent postmenopausal osteoporosis. Description Estradiol and norethindrone combination is used to treat moderate to severe symptoms of menopause (eg, feelings of warmth in the face, neck, and chest, sudden strong feelings of heat and sweating [hot flashes], and vaginal problems). This medicine is also used prevent osteoporosis after menopause. This medicine is available only with your doctor's prescription. Estradiol; Norethindrone Tablets What is this medication? ESTRADIOL; NORETHINDRONE (es tra DYE ole; nor eth IN drone) relieves the symptoms of menopause, such as hot flashes or vaginal dryness. It may also be used to prevent osteoporosis. It works by increasing levels of the hormones estrogen and progestin in your body. Estradiol and norethindrone transdermal (skin patch) is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes. estradiol and norethindrone is also used before menopause to treat a lack of estrogen caused by conditions such as hypogonadism, primary ovarian failure, or surgical removal of the ovaries. Description Estradiol and norethindrone skin patch is used to treat moderate to severe hot flashes and other symptoms of menopause. It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. Estradiol and norethindrone is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estradiol and norethindrone may also be used for purposes not listed in this medication guide. Find patient medical information for Estradiol/Norethindrone (CombiPatch, Activella, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. This information from UpToDate® Lexidrug™ explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Activella (estradiol / norethindrone) is a hormone replacement therapy (HRT) that replaces estrogen and progesterone hormones during menopause: Estradiol is an estrogen replacement. It lowers the risk of bone loss and eases certain symptoms of low estrogen, such as hot flashes, night sweats, and vaginal dryness. Norethindrone is a progestin. Following continuous dosing with once-daily administration of estradiol and norethindrone acetate tablets 1 mg/0.5 mg, serum concentrations of estradiol, estrone, and norethindrone reached steady-state within two weeks with an accumulation of 33 to 47% above concentrations following single dose administration.