Medscape - Diabetes type 2-specific dosing for Glucophage, Glucophage XR (metformin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation. Sign up today to receive the latest news and updates from UpToDate. © 2026 UpToDate, Inc. and/or its affiliates. All Rights Reserved. Metformin dosage guide covering starting doses, maximum daily doses, extended-release dosing, kidney function, and dose adjustments. Metformin alone: At first, 500 milligrams (mg) two times a day taken with the morning and evening meals, or 850 mg a day taken with the morning meal. Your doctor may adjust your dose if needed until your blood sugar is controlled. Learn the safe starting dose, how to titrate, max daily limit, and cost-saving tips for metformin in type 2 diabetes and off-label weight control. Detailed Metformin dosage information for adults and children. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis adjustments. This article describes the dosages of metformin, as well as its strengths and how to take it. When taking metformin, always follow the dosage prescribed by your doctor. Immediate-release metformin is typically taken twice daily with breakfast and dinner, while extended-release metformin is usually taken once daily with the evening meal. Our comprehensive metformin dosage guide and chart breaks down starting doses, maximum limits, and timing recommendations for both immediate-release and extended-release formulations. Typically, metformin treatment starts with a lower dose, such as 500 milligrams (mg) twice daily or 850 mg once daily. The exact dosage is tailored based on individual health factors under the guidance of a healthcare professional. For adults, the daily metformin dosage should not exceed 2,550 mg.