Target dosing: 850 mg PO q12hr. Hepatic impairment: Avoid use; risk of lactic acidosis. Orphan designation for treatment of pediatric polycystic ovary syndrome. Indicated as an adjunct to diet and. This article describes the dosages of metformin, as well as its strengths and how to take it. When taking metformin, always follow the dosage prescribed by your doctor. Typically, metformin treatment starts with a lower dose, such as 500 milligrams (mg) twice daily or 850 mg once daily. The exact dosage is tailored based on individual health factors under the guidance of a healthcare professional. For adults, the daily metformin dosage should not exceed 2,550 mg. Metformin doses vary by age, condition, and kidney health. Here’s what typical dosing looks like for adults, kids, and those with PCOS. Metformin dosage guide covering starting doses, maximum daily doses, extended-release dosing, kidney function, and dose adjustments. Learn how metformin treats type 2 diabetes, including dosage, side effects, warnings, and its off-label use for weight loss and PCOS. Reviewed drug info Our comprehensive metformin dosage guide and chart breaks down starting doses, maximum limits, and timing recommendations for both immediate-release and extended-release formulations. View metformin hydrochloride information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and monitoring requirements. Metformin alone: At first, 500 milligrams (mg) two times a day taken with the morning and evening meals, or 850 mg a day taken with the morning meal. Your doctor may adjust your dose if needed until your blood sugar is controlled. Detailed Metformin dosage information for adults and children. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis adjustments.